Design of On-Target FAAH Inhibitors
نویسندگان
چکیده
منابع مشابه
Design of on-target FAAH inhibitors.
In this issue of Chemistry & Biology, Alexander and Cravatt propose a model for the binding of carbamate inhibitors to fatty acid amide hydrolase (FAAH), the enzyme that breaks down signaling lipids. Using competitive activity-based protein profiling and click chemistry, they designed potent and selective FAAH inhibitors and characterized their off-target reactions.
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We need better medicines to control acute and chronic pain. Fatty acid amide hydrolase (FAAH) and soluble epoxide hydrolase (sEH) catalyze the deactivating hydrolysis of two classes of bioactive lipid mediators--fatty acid ethanolamides (FAEs) and epoxidized fatty acids (EpFAs), respectively--which are biogenetically distinct but share the ability to attenuate pain responses and inflammation. I...
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ژورنال
عنوان ژورنال: Chemistry & Biology
سال: 2005
ISSN: 1074-5521
DOI: 10.1016/j.chembiol.2005.11.001